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PubMed · 3522673

Giant cell lichenoid dermatitis.

J G Gonzalez·M D Marcus·D J Cruz
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Abstract

A case of drug-induced lichenoid dermatitis with an unusual epidermotropic multinucleated giant cell inflammatory response is reported. The patient is a 52-year-old white woman who is steroid-dependent because of long-standing systemic lupus erythematosus. At the time of presentation of her generalized papulosquamous pruritic eruption, she was taking oral antihypertensive medications (methyldopa and chlorothiazide). After discontinuation of these medications and local treatment with topical corticosteroids, the skin eruption dramatically improved. Microscopically, the skin lesions had a lichenoid inflammatory pattern, with multiple cytoid bodies, multinucleated giant cells, and a mixed chronic inflammatory infiltrate that included lymphocytes, histiocytes, and eosinophils.

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ChlorothiazideFemaleFluorescent Antibody TechniqueHumansLichen PlanusMethyldopaMiddle AgedSkinCase ReportsJournal Article

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BibTeXRIS

J G Gonzalez, M D Marcus, D J Cruz. 1986. Giant cell lichenoid dermatitis.. https://doi.org/10.1016/s0190-9622(86)70148-5

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Chlorothiazide↗
PubMed1998

Spectrophotometric studies on the photostability of some thiazide diuretics in ethanolic solution.

First derivative and dual-wavelength spectrophotometric methods were used in the quantum yield determination of the photochemical decomposition reactions of three thiazide diuretics (chlorothiazide, hydrochlorothiazide and trichloromethiazide) in ethanolic solution. The radiation absorbed by the compounds was measured using iron(III) oxalate actinometry based on absorption spectrophotometry. An apparatus is described in which the drugs were irradiated in quartz cuvettes cooled by water in a stand built on a magnetic stirrer. The wavelength region available to the reaction cuvette was restricted to 313 nm with chemical potassium chromate filter solutions and a Corning filter plate. Chlorothiazide proved to be more photostable than hydrochlorothiazide and trichloromethiazide in ethanol.

Chlorothiazide↗