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alpha-Methyldopa for climacteric hot flushes. A double-blind, randomized, cross-over study.

O Andersen·T Engebretsen·V M Solberg·A Orbo
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Abstract

The effects of single evening doses of alpha-methyldopa and placebo have been compared in 40 women with climacteric hot flushes. The study was designed as a double-blind, randomized and cross-over investigation. Of the 24 patients who completed the study, 15 reported that they preferred the alpha-methyldopa treatment (p greater than 0.05). alpha-methyldopa seemed to affect both the severity (p less than 0.05) and the frequency of climacteric hot flushes (p greater than 0.05). It is concluded that alpha-methyldopa is efficacious against climacteric hot flushes when given as single evening doses, but further study is required to answer whether this dosage is as effective as a twice daily regimen.

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ClimactericClinical Trials as TopicDouble-Blind MethodFemaleFlushingHumansMethyldopaMiddle AgedRandom AllocationClinical TrialJournal ArticleRandomized Controlled Trial

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O Andersen, T Engebretsen, V M Solberg, A Orbo. 1986. alpha-Methyldopa for climacteric hot flushes. A double-blind, randomized, cross-over study.. https://doi.org/10.3109/00016348609157373

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