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PubMed · 353960

Circulating immune complexes in nephritis.

R Coppo·M De Marchi·G Segoloni·F Quarello·G Piccoli
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Abstract

Serum samples from 115 patients with various kidney disease were studied by means of precipitation in 3.5% polyethylene-glycol (the PEG test) and by inhibition of agglutination of IgG-coated polystyrene particles induced by C1q, two tests developed for the detection of circulating immune complexes. Positive results were found in acute glomerulonephritis, particularly in its early stages, and also in chronic forms of glomerulonephritis: membranous, focal sclerosing, mesangiocapillary and focal glomerulonephritis. High levels of circulating immune complexes were found in lupus nephritis. In most cases the test results showed a good correlation with the clinical course of the diseases.

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Antigen-Antibody ComplexChemical PrecipitationComplement C3Complement C4CryoglobulinsGlomerulonephritisHumansImmunologic TechniquesLatex Fixation TestsLupus Erythematosus, SystemicNephritis, InterstitialPolyethylene GlycolsJournal Article

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R Coppo, M De Marchi, G Segoloni, F Quarello, G Piccoli. Circulating immune complexes in nephritis.. https://doi.org/10.1007/bf02886648

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Immune complexes and the evolution of Lyme arthritis. Dissemination and localization of abnormal C1q binding activity.

In a prospective study of 78 patients with Lyme arthritis, abnormal serum C1q binding activity was present at the initial onset of erythema chronicum migrans in nearly all cases. The abnormal binding persisted in patients with subsequent nerve or heart involvement. In contrast, among those with only subsequent arthritis, it usually disappeared within three months (P = 0.018). However, in the synovial fluid of affected joints, abnormal binding was uniformly present, and always to a greater extent than in the circulation. The abnormally reactive material behaved like antigen-antibody complexes. It had a density of 19S or greater, dissociated below pH 4.2, and lacked antiglobulin activity. Cryoprecipitates containing immunoglobulin were good but insensitive predictors of its presence, but immune complexes themselves did not seem primarily responsible for cryoprecipitability. Thus, as judged by C1q binding, immune complexes remain disseminated in certain patients with Lyme arthritis but localize to joints in others.

Antigen-Antibody Complex↗