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PubMed · 36114

[Effect of a new beta-blocking drug (SP/1601) on the extension of experimental acute infarct in anesthetized dogs].

L Merlo·B Brusoni·G Marchetti
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Adrenergic beta-AntagonistsAnimalsDrug Evaluation, PreclinicalElectrocardiographyHemodynamicsMaleMyocardial ContractionMyocardial InfarctionPropanolaminesJournal Article

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L Merlo, B Brusoni, G Marchetti. 1977. [Effect of a new beta-blocking drug (SP/1601) on the extension of experimental acute infarct in anesthetized dogs].. https://pubmed.ncbi.nlm.nih.gov/36114/

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PubMed1979

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Three groups of patients with different premedications were examined for changes of blood pressure, heart rate, ECG and plasma free fatty acid levels during esophago-gastro-duodenoscopy: Group A was premedicated with Bunitrolol, group B was premedicated with Hyoscin-N-butyl-bromide and diazepam, group C was endoscopied without premedication. The pulse rate rose significantly less in group A than in groups A and C; the same phenomenon was observed with regard to the systolic blood pressure. Premature beats occurred in all 3 groups: 32 per cent of the patients in group A, 43 per cent in group B and 60 per cent in group C had at least occasional premature beats; an accumulation of premature beats however occurred significantly less frequently in group A than in groups B or C. A drop of the ST-part of the ECG occurred with about the same frequency in each group. An increase of the plasma free fatty acids, which was noted in groups B and C, could be observed in Group A. A pre-endoscopic medication of beta blocking agents could be a useful measure in patients with labile arterial hypertension, vegatative dysregulation and a hyperkinetic heart syndrome.

Adrenergic beta-Antagonists↗
PubMed1979

Antihypertensive and cardiac effects of two novel beta-adrenoceptor blocking drugs.

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Adrenergic beta-Antagonists↗