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PubMed · 362670

Heparin as antibacterial agent in rabbit bladder.

P M Hanno·R Fritz·A J Wein·S G Mulholland
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Abstract

Previous studies performed in our laboratory indicated that the primary antibacterial defense mechanism of the rabbit bladder is the antiadsorptive action of the surface mucopolysaccharide. The increased bacterial adsorption that occurs when the bladder is denuded of this layer was prevented by the instillation of heparin. Additional studies showed that the protective effect of heparin is inhibited by protamine, a further indication that the bladder's "antiadherence factor" is a mucopolysaccharide. Small amounts of heparin, applied directly to the mucoprotein-deficient bladder or to the surface of the inoculated bacteria, produced a statistically significant reduction in bacterial adsorption.

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AdsorptionAnimalsAnti-Infective Agents, UrinaryEscherichia coliHeparinHeparin AntagonistsMaleModels, BiologicalMucoproteinsMucous MembraneProtaminesRabbitsUrinary BladderUrinary Tract InfectionsJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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P M Hanno, R Fritz, A J Wein, S G Mulholland. 1978. Heparin as antibacterial agent in rabbit bladder.. https://doi.org/10.1016/0090-4295(78)90291-1

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