Myopathy with core-like structures in a dog.

S J Newsholme; C J Gaskell

doi:10.1016/0021-9975(87)90010-7

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Myopathy with core-like structures in a dog.

S J Newsholme·C J Gaskell

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Abstract

Core-like structures were seen histologically in many of the fibres of the triceps and biceps femoris muscles of an 18-months-old male Great Dane with muscle weakness and moderate proximal muscular atrophy. The structures were lightly staining and lacked cross-striations. Some contained vacuoles and nuclei. Scattered necrotic and presumably regenerating fibres were also present. Ultrastructurally, the cores contained disarrayed filament bundles attached to thickened Z-lines which were compatible with the rods of rod myopathies. The condition was not fully characterized, but has certain similarities to a group of rare human congenital muscular disorders which includes central core disease.

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Actin Cytoskeleton Animals Dog Diseases Dogs Male Microscopy, Electron Muscles Muscular Diseases Case Reports Journal Article

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S J Newsholme, C J Gaskell. 1987. Myopathy with core-like structures in a dog.. https://doi.org/10.1016/0021-9975(87)90010-7

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