[Collagenous colitis].

Abstract

The authors report two new observations of collagenous colitis. In both cases the signs were of functional colonopathy, and the diagnosis was only made after rectal and colic biopsies. In one case, electron microscopy revealed that the collagen band was independent of the epithelial membrane. The collagenous deposit contained many nerve endings, which seems to suggest an inflammatory origin of the disease. The clinical condition of a female patient was greatly improved by mepacrine, but the histological lesions remained unchanged.