New bone formation in acromegaly: pathogenetic implications for diffuse idiopathic skeletal hyperostosis.

G O Littlejohn; S Hall; C A Brand; A Davidson

PubMed · 3731577

New bone formation in acromegaly: pathogenetic implications for diffuse idiopathic skeletal hyperostosis.

G O Littlejohn·S Hall·C A Brand·A Davidson

Abstract

Radiographs of spinal and heel entheseal areas and the skull were examined for new bone formation in 30 acromegalic patients. Forty-seven percent satisfied accepted criteria for Diffuse Idiopathic Skeletal Hyperostosis (DISH), 67% had marked heel enthesopathic change and 87% had Hyperostosis Frontalis Interna (HFI). Such hyperostotic changes were indistinguishable from those seen in DISH and the extent and degree of such changes increased with duration of acromegaly. It is proposed that a common metabolic factor, e.g., hyperinsulinaemia, may be responsible for the hyperostotic changes seen in both DISH and acromegaly.

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Acromegaly Adolescent Adult Aged Aging Female Heel Humans Hyperostosis Frontalis Interna Male Middle Aged Osteochondrodysplasias Osteogenesis Radiography Spine Journal Article Research Support, Non-U.S. Gov't

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G O Littlejohn, S Hall, C A Brand, A Davidson. New bone formation in acromegaly: pathogenetic implications for diffuse idiopathic skeletal hyperostosis.. https://pubmed.ncbi.nlm.nih.gov/3731577/

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PubMed2007

Acromegaly.

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Acromegaly↗

PubMed2007

Carney complex: the first 20 years.

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