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PubMed · 3746309

Decision-making in refractory epilepsy: an analysis based on computer simulation.

C D Ward
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Abstract

A program developed to simulate management of patients with recurrent seizures was tested in 24 subjects, including 13 experienced neurologists. Identifiable errors included excessive reliance on plasma anticonvulsant levels, misinterpretation of random effects, inefficiency in selection of follow-up intervals, and undue reference to arbitrary data, such as the initial dose, in the selection of "optimum" drug dosage.

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CarbamazepineComputersEpilepsyHumansModels, TheoreticalPatient CompliancePhenytoinJournal Article

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C D Ward. 1986. Decision-making in refractory epilepsy: an analysis based on computer simulation.. https://doi.org/10.1136/jnnp.49.7.781

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An immunodominant haptenic epitope of carbamazepine detected in serum from patients given long-term treatment with carbamazepine without allergic reaction.

An anticarbamazepine antibody was detected in the serum of a patient with severe carbamazepine-induced serum sickness. We found that the patient's T cells and IgG antibody recognized an epitope which appeared in subjects showing an allergic reaction, as well as that in subjects who showed no allergic reaction, after long-term carbamazepine therapy. These results show that an anti-carbamazepine immune response does not occur in the majority of subjects who undergo long-term carbamazepine therapy without developing allergic symptoms, although the immunodominant haptenic epitope of carbamazepine is present in their sera.

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