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Helodermin has a VIP-like effect upon canine blood flow.

S Naruse·A Yasui·S Kishida·M Kadowaki·M Hoshino·T Ozaki·P Robberecht·J Christophe·C Yanaihara·N Yanaihara
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Abstract

The effect of helodermin on vascular physiology was studied in anesthetized dogs using a synthetic replicate of helodermin and helodermin related peptides. Intraarterial infusion of helodermin caused a dose-dependent increase in femoral blood flow. Helodermin was 16 times less potent than VIP and 5 times more potent than PHM (human PHI). The helodermin effect lasted significantly longer; the half-life of the helodermin effect was 6.5 times longer than VIP. Synthetic helodermin (Hd) N-terminal fragment Hd(1-27)NH2 retained substantial activity similar to the full helodermin molecule but the prolonged effect was lost. Hd(7-35) and Hd(22-35) were inactive in this system. Intravenous injection of synthetic helodermin produced prolonged systemic hypotension and tachycardia; and, similar to VIP, it increased the common carotid arterial blood flow while those of the superior mesenteric and femoral arteries were decreased. The results demonstrate the VIP-like vasodilating activity and cardiovascular effects of helodermin in anesthetized dogs.

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AnimalsCardiovascular Physiological PhenomenaCardiovascular SystemDogsFemaleHemodynamicsIntercellular Signaling Peptides and ProteinsMalePeptidesRegional Blood FlowVasoactive Intestinal PeptideVasodilationJournal ArticleResearch Support, Non-U.S. Gov't

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S Naruse, A Yasui, S Kishida, M Kadowaki, M Hoshino, T Ozaki, P Robberecht, J Christophe, C Yanaihara, N Yanaihara. 1986. Helodermin has a VIP-like effect upon canine blood flow.. https://doi.org/10.1016/0196-9781(86)90192-0

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