A multiple sequence alignment program.

E Sobel; H M Martinez

doi:10.1093/nar/14.1.363

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A multiple sequence alignment program.

E Sobel·H M Martinez

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Abstract

A program is described for simultaneously aligning two or more molecular sequences which is based on first finding common segments above a specified length and then piecing these together to maximize an alignment scoring function. Optimal as well as near-optimal alignments are found, and there is also provided a means for randomizing the given sequences for testing the statistical significance of an alignment. Alignments may be made in the original alphabets of the sequences or in user-specified alternate ones to take advantage of chemical similarities (such as hydrophobic-hydrophilic).

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Amino Acid Sequence Base Sequence Computers Repetitive Sequences, Nucleic Acid Software Journal Article Research Support, U.S. Gov't, Non-P.H.S.

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E Sobel, H M Martinez. 1986-01-10. A multiple sequence alignment program.. https://doi.org/10.1093/nar%2F14.1.363

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