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PubMed · 3759368

Lectin binding to pseudoexfoliative material and the ocular zonules.

Abstract

Lectin staining of pseudoexfoliative material on the lens capsule, zonules, and iris showed the presence of the beta-D-galactose (1-3) galactosamine sequence, alpha-D-galactosamine, beta-D-galactose, beta-(1-4)-D-glucosamine, and terminal sialic acid. Mono and difucosyl binding sites were also found. The likelihood that the lectins were binding to two different galactosamine-containing moieties was supported by their different distributions in the photoreceptors. These affinities suggest a complex carbohydrate composition in pseudoexfoliative material, with both O-linked sialomucin-type and N-linked oligosaccharide chains.

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BibTeXRIS

B W Streeten, S A Gibson, Z Y Li. 1986. Lectin binding to pseudoexfoliative material and the ocular zonules.. https://pubmed.ncbi.nlm.nih.gov/3759368/

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Postmortem microscopic evaluation and clinical correlation of a pseudophakic eye with pseudoexfoliation and loss of zonular support.

We describe a pseudophakic patient with pseudoexfoliation who developed late intraocular lens (IOL) instability manifested by pseudophakodonesis, a change in refraction, and loss of glaucoma control. The patient subsequently required glaucoma surgery that was complicated by vitreous loss. Preoperative ultrasound biomicroscopy (UBM) failed to provide useful information regarding the zonular status. The patient died as a result of a malignancy, and the eye was donated for research. Anatomical evaluation confirmed the clinical impression of IOL placement in the bag and zonular laxity. Postmortem UBM helped explain some of the technical difficulties in examining zonules in the pseudophakic state.

Anterior Eye Segment↗