[Modern study methods in experimental nephrology].

Abstract

The investigation technique of the experimental nephrology comprise in-vivo and in-vitro methods. This order results from the increasing reduction of the size of the investigation object, beginning with the kidneys in the intact organism up to the subcellular structures. Modern investigation techniques such as the nuclear magnetic resonance spectrometry or the tubular microperfusion method with or without ion-selective micropotential measurement have opened new ways of approach and led to new recognitions concerning the function of the kidney in physiological and pathophysiological situations. To this among others belong the characterization of the tubulo-glomerular feedback and aspects of the humoral regulation of renal compensatory adaptation processes. It remains open whether in near future a new stage of experimental nephrology is beginning. It might take its starting point from the cultivation of nephronal cells and via bioartificial hybrid systems lead to new ways in simulating the tubular renal function.