A simple algorithm for the solution of the multiple dosing problem.

Abstract

A system theoretical approach to the general multiple dosing problem is discussed [1], which is in turn reduced to a classical parameter optimization problem. An efficient numerical algorithm based on the cyclic coordinate search method to solve the latter is explained. A flexible and user-friendly program written in standard FORTRAN which is suitable for this problem is introduced. Finally, the problem is applied to the dopaminergic substitution problem in Parkinson's disease, and the necessary input data as well as the resulting output is displayed in a sample run.