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PubMed · 3898710

Genetic factors affecting hearing development.

K P Steel·G R Bock
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Abstract

Both genetic background and single gene mutations may affect the development of the auditory system. A classification system is presented for those single gene mutations causing hearing impairment. The new feature of this classification is the inclusion of a category for hereditary deafness of central origin. The other categories involve peripheral abnormalities and are: morphogenetic defects, in which the overall structure of the labyrinth is deformed; neuroepithelial degeneration, in which the primary defect appears to occur in the organ of Corti; and cochleo-saccular degeneration, where the stria vascularis is abnormal and Reissner's membrane collapses, leading to further degeneration.

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AnimalsAuditory PathwaysCochleaDisease Models, AnimalEar, InnerEmbryonic InductionHearing DisordersHumansMiceMice, Neurologic MutantsMorphogenesisMutationPeromyscusRatsRats, GunnReflex, StartleSaccule and UtricleSensory DeprivationJournal ArticleReview

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K P Steel, G R Bock. 1985. Genetic factors affecting hearing development.. https://doi.org/10.3109/00016488509121756

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