Renal osteodystrophy--pathogenesis and treatment.

H M Cushner; N D Adams

doi:10.1097/00000441-198512000-00003

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Renal osteodystrophy--pathogenesis and treatment.

H M Cushner·N D Adams

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Abstract

Histologic bone changes of osteitis fibrosa and osteomalacia are commonly present in patients with end-stage renal disease. Although many patients are not symptomatic from these bone changes, some patients are severely disabled. Altered metabolism of vitamin D, calcium, phosphorus, and parathyroid hormone occurs in renal failure and contributes to the development of uremic bone disease. This article reviews the current theories of pathogenesis and treatment of renal osteodystrophy. In addition, the clinical presentation, pathogenesis, and treatment of the various aluminum-associated osteomalacic syndromes in uremia are discussed.

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Aluminum Bone and Bones Calcitriol Calcium Calcium, Dietary Chronic Kidney Disease-Mineral and Bone Disorder Humans Kidney Failure, Chronic Osteitis Fibrosa Cystica Osteomalacia Parathyroid Hormone Phosphorus Renal Dialysis Vitamin D Journal Article Research Support, U.S. Gov't, P.H.S.Review

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H M Cushner, N D Adams. 1985. Renal osteodystrophy--pathogenesis and treatment.. https://doi.org/10.1097/00000441-198512000-00003

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