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PubMed · 39246

Simultaneous determination of beta-1 and beta-2-adrenergic receptors in tissues containing both receptor subtypes.

K P Minneman·L R Hegstrand·P B Molinoff
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Adrenergic beta-AgonistsAdrenergic beta-AntagonistsAnimalsBinding, CompetitiveBrainComputersIn Vitro TechniquesKineticsLungMaleMethodsMyocardiumPhentolaminePindololRatsReceptors, AdrenergicReceptors, Adrenergic, betaJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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K P Minneman, L R Hegstrand, P B Molinoff. 1979. Simultaneous determination of beta-1 and beta-2-adrenergic receptors in tissues containing both receptor subtypes.. https://pubmed.ncbi.nlm.nih.gov/39246/

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PubMed1979

In vitro modulation of CNS beta-receptor number by antidepressants and beta-agonists.

In vitro incubation of rat cerebral cortex slices with antidepressant drugs reduced beta-adrenergic receptor binding of 3H-dihydroalprenolol by 30%. The decrease was maximum after 60 min, and was reversible after 120 min. (-)-Isoproterenol incubation caused a rapid and reversible loss (60%) of beta-receptor binding. Both effects were due to a decrease in beta-receptor sites. In vitro beta-receptor subsensitivity due to desipramine and isoproterenol was non-additive. The observed reversible loss of beta-receptor sites may be an initial phase of the beta-receptor down-regulation by antidepressants seen in vivo.

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