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PubMed · 395087

Development of a closed-loop artificial pancreas.

E W Kraegen·R Whiteside·D Bell·Y O Chia·L Lazarus
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Abstract

A closed-loop glucose controlled insulin infusion system was developed, consisting of elements for continuous blood glucose analysis, a computer control system, and infusion systems. Improvements include decreased size, cost reduction and better performance. The algorithm used was a piecewise linear representation of the sigmoidal curve commonly employed. The apparatus has been applied to simulation of the healthy beta cell and glucose clamp studies.

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Artificial OrgansAutoanalysisBlood GlucoseComputersDiabetes MellitusEatingFeedbackHumansInfusions, ParenteralInsulinIslets of LangerhansJournal Article

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E W Kraegen, R Whiteside, D Bell, Y O Chia, L Lazarus. 1979. Development of a closed-loop artificial pancreas.. https://pubmed.ncbi.nlm.nih.gov/395087/

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