Effect of strophantin on the isolated guinea-pig ileum.

R Soares de Moura; D A Ribeiro Santos; J R Sollero Caiaffa

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PubMed · 39531

Effect of strophantin on the isolated guinea-pig ileum.

R Soares de Moura·D A Ribeiro Santos·J R Sollero Caiaffa

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Abstract

The effect of strophantin on isolated guinea-pig ileum was investigated. It was found that strophantin produces a dose-dependent contraction that is not blocked by atropine, ganglionic blockade, but is potentiated by prostigmine. Depolarization of the guinea-pig ileum by a high potassium solution does not change the effect of strophantin. Strophantin response is competitively antagonized by verapamil. The effect is significantly reduced, 5 to 10 min, after the preparation is immersed in zero calcium Tyrode solution. These results support the view that the effect of strophantin is dependent on the influx of calcium through the cell membrane.

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Animals Calcium Drug Interactions Female Ganglionic Blockers Guinea Pigs Ileum In Vitro Techniques Male Muscle Contraction Muscle, Smooth Neostigmine Parasympatholytics Strophanthins Verapamil Journal Article

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R Soares de Moura, D A Ribeiro Santos, J R Sollero Caiaffa. 1979. Effect of strophantin on the isolated guinea-pig ileum.. https://pubmed.ncbi.nlm.nih.gov/39531/

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