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PubMed · 3955798

Pneumococcus-specific immunoglobulin E in cigarette smokers.

J W Bloom·M Halonen·A M Dunn·J L Pinnas·B Burrows
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Abstract

A relationship between elevated serum immunoglobulin E levels and smoking has been demonstrated in epidemiological studies. Allergy skin test data suggest that the excess immunoglobulin E of smokers is not specific for aeroallergens. It is possible that the excess immunoglobulin E is specific for microorganisms that often infect the lower respiratory tract of smokers. To investigate this possibility we utilized a radioallergosorbent test assay for detecting serum immunoglobulin E specific for Streptococcus pneumoniae, an organism commonly isolated from the respiratory tract of smokers with chronic bronchitis. We assayed sera of thirty smokers and thirty nonsmokers for immunoglobulin E specific for Streptococcus pneumoniae. Individual sera were considered positive for pneumococcus-specific immunoglobulin E if the binding was at least twice the non-specific binding at the total immunoglobulin E concentration of the particular serum. Eleven of the thirty sera of smokers and two of the thirty nonsmokers were positive for pneumococcus-specific immunoglobulin E. By chi-square analysis of these data, the prevalence of pneumococcus-specific immunoglobulin E was significantly greater in the smoking group compared with the non-smoking group (P less than 0.02). These results suggest that the excess immunoglobulin E of smokers is, at least in part, specific for microorganisms that infect the airways.

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AdultAgedAntibody SpecificityArizonaBronchitisEnvironmental MonitoringHumansImmunoglobulin EMiddle AgedRadioallergosorbent TestRadioimmunosorbent TestSmokingStaphylococcus aureusStreptococcus pneumoniaeComparative StudyJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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J W Bloom, M Halonen, A M Dunn, J L Pinnas, B Burrows. 1986. Pneumococcus-specific immunoglobulin E in cigarette smokers.. https://doi.org/10.1111/j.1365-2222.1986.tb01950.x

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