Multicompartment kinetic models for lead. I. Bone diffusion models for long-term retention.

A H Marcus

doi:10.1016/0013-9351(85)90037-4

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Multicompartment kinetic models for lead. I. Bone diffusion models for long-term retention.

A H Marcus

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Abstract

The long-term retention of lead in bone poses a number of difficulties for the usual multicompartment models. The use of diffusion models based on exchange of lead between blood in canaliculi and the crystalline bone of the osteon allows a linear compartmental approximation suitable for statistical estimation of kinetic parameters in peripheral compartments. The model is applied to lead retention by beagle dogs.

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Animals Body Burden Bone and Bones Diffusion Dogs Humans Kinetics Lead Models, Biological Journal Article

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A H Marcus. 1985. Multicompartment kinetic models for lead. I. Bone diffusion models for long-term retention.. https://doi.org/10.1016/0013-9351(85)90037-4

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