A dose-response model for teratological experiments involving quantal responses.

K Rai; J Van Ryzin

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PubMed · 4005367

A dose-response model for teratological experiments involving quantal responses.

K Rai·J Van Ryzin

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Abstract

This paper introduces a dose-response model for teratological quantal response data where the probability of response for an offspring from a female at a given dose varies with the litter size. The maximum likelihood estimators for the parameters of the model are given as the solution of a nonlinear iterative algorithm. Two methods of low-dose extrapolation are presented, one based on the litter size distribution and the other a conservative method. The resulting procedures are then applied to a teratological data set from the literature.

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Abnormalities, Drug-Induced Biometry Environmental Pollution Female Humans Mathematics Models, Biological Pregnancy Probability Teratogens Journal Article Research Support, U.S. Gov't, P.H.S.

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K Rai, J Van Ryzin. 1985. A dose-response model for teratological experiments involving quantal responses.. https://pubmed.ncbi.nlm.nih.gov/4005367/

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