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PubMed · 4033820

[Consensus "policy regarding thrombocyte transfusions"].

W G van Aken·J A van der Does·C Dudok de Wit
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Blood Platelet DisordersBlood TransfusionHumansNetherlandsPeer ReviewPlatelet TransfusionPublic PolicyQuality Assurance, Health CareEnglish AbstractJournal Article

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W G van Aken, J A van der Does, C Dudok de Wit. 1985-07-20. [Consensus "policy regarding thrombocyte transfusions"].. https://pubmed.ncbi.nlm.nih.gov/4033820/

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May-Hegglin anomaly: a rare cause of thrombocytopenia.

A family with four and an unrelated family with three individuals affected by the May-Hegglin anomaly are described. Platelet counts were markedly reduced and were correctly determined only in the counting chamber. Bleeding time and platelet aggregation were always normal, but platelet nucleotide concentrations (ATP and ADP) were elevated. The platelet glycoprotein complexes Ib/IX, IIb/IIIa and Ia/IIa were quantitatively normal. Platelet-associated IgG was slightly elevated, although thrombocytopenia was presumably not caused by an immunological mechanism. Morphological investigations showed giant platelets and spindle-shaped inclusion bodies in the granulocytes, while their function (phagocytic capacity, radical production) was normal. To exclude hereditary types of thrombocytopenia, morphological and family investigations are required to avoid misdiagnosis with far-reaching diagnostic and therapeutic consequences.

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