Toluene embryopathy.

J H Hersh; P E Podruch; G Rogers; B Weisskopf

doi:10.1016/s0022-3476(85)80238-9

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Toluene embryopathy.

J H Hersh·P E Podruch·G Rogers·B Weisskopf

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Abstract

Three children with microcephaly, central nervous system dysfunction, minor craniofacial and limb anomalies, and variable growth deficiency were born to women who inhaled large quantities of pure toluene throughout pregnancy. The features in our patients were reminiscent of the patterns of malformation previously described following in utero exposure to alcohol, certain anticonvulsants, and hyperphenylalaninemia. It is possible that there is a variable and nonspecific teratogenic phenotype characterized by alterations in growth, development, and morphogenesis. Careful evaluation and monitoring of infants exposed to toluene in utero are needed to determine the significance of our findings.

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Abnormalities, Drug-Induced Child, Preschool Environmental Pollution Female Growth Disorders Humans Male Maternal-Fetal Exchange Microcephaly Pregnancy Syndrome Toluene Case Reports Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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J H Hersh, P E Podruch, G Rogers, B Weisskopf. 1985. Toluene embryopathy.. https://doi.org/10.1016/s0022-3476(85)80238-9

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