From genes to geometry: Controlling embryo models by programming genomic activation.

Harold M McNamara; Berna Sozen

doi:10.1016/j.stem.2025.04.013

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From genes to geometry: Controlling embryo models by programming genomic activation.

Harold M McNamara·Berna Sozen

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Abstract

Embryo-like models derived from stem cells have emerged as powerful tools to study early development. In this issue, Lodewijk et al.1 demonstrate that activating just two enhancers via CRISPR activation (CRISPRa) in mouse embryonic stem cells (ESCs) can drive self-organization into structured embryo-like models, offering a genome-driven approach in stem cell and developmental biology.

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Animals Mice Embryo, Mammalian Mouse Embryonic Stem Cells CRISPR-Cas Systems Embryonic Stem Cells Genome Models, Biological Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Comment

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Harold M McNamara, Berna Sozen. 2025-06-05. From genes to geometry: Controlling embryo models by programming genomic activation.. https://doi.org/10.1016/j.stem.2025.04.013

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