[Test systems for biomonitoring based on membrane-bound enzyme complexes. V. Mixed-function monooxygenase induction in the liver microsomes of Lake Baikal fish].

L I Stepanova; S V Kotelevtsev; P G Komarov; K N Novikov; V M Glazer

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PubMed · 4063411

[Test systems for biomonitoring based on membrane-bound enzyme complexes. V. Mixed-function monooxygenase induction in the liver microsomes of Lake Baikal fish].

L I Stepanova·S V Kotelevtsev·P G Komarov·K N Novikov·V M Glazer

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Abstract

The content of cytochrome P450 and monooxygenase activity has been studied in the liver of Baikal fishes (Coregonus automnalis, Thymallus articus, Brachymystax lenok and Cottocomphorus greminsky). The administration of 3-methylcholanthrene increases considerably the level of metabolic activity of microsomal fraction and cytochrome P450 content in liver. The data of microsomal fractions of rats and fishes liver electrophoresis have shown that xenobiotic causes the synthesis of similar according to the molecular weight forms of cytochrome P450 in these animals. The induction of microsomal monooxygenase inhibits the lipid peroxidation of microsomal fraction.

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Animals Cytochrome P-450 Enzyme System Environmental Monitoring Enzyme Induction Fishes Lipid Peroxides Methylcholanthrene Microsomes, Liver Mixed Function Oxygenases Oxidation-Reduction Rats Siberia Comparative Study English Abstract Journal Article

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L I Stepanova, S V Kotelevtsev, P G Komarov, K N Novikov, V M Glazer. 1985. [Test systems for biomonitoring based on membrane-bound enzyme complexes. V. Mixed-function monooxygenase induction in the liver microsomes of Lake Baikal fish].. https://pubmed.ncbi.nlm.nih.gov/4063411/

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