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PubMed · 4075784

On statistical comparison of two diagnostic tests.

E A Balás·J Mérei
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Abstract

A one-sample hypothesis testing method is presented for comparing the accuracy of two diagnostic tests. Costs and inconveniences related to the false positive and false negative diagnostic test results, to the extent that they are quantifiable, are considered as measures of the importance of avoiding misclassification. The use of the proposed method is illustrated by comparing the effectiveness of aspiration biopsy cytology and frozen section in detecting malignant thyroid disease.

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Biopsy, NeedleDiagnosisFalse Negative ReactionsFalse Positive ReactionsFrozen SectionsHumansHypoparathyroidismRecurrent Laryngeal Nerve InjuriesStatistics as TopicThyroid NeoplasmsThyroidectomyComparative StudyJournal ArticleResearch Support, Non-U.S. Gov't

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E A Balás, J Mérei. 1985. On statistical comparison of two diagnostic tests.. https://doi.org/10.1016/0010-4809(85)90025-4

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Targeting difficult accessible breast lesions: MRI-guided needle localization using a freehand technique in a 3.0 T closed bore magnet.

PURPOSE: To report the accuracy of magnetic resonance imaging (MRI)-guided needle localization for diagnosis of MRI detected suspicious breast lesions located in difficult accessible regions of the breast, using the freehand method in a 3.0 T closed bore magnet. MATERIALS AND METHODS: In five patients with five MRI-only breast lesions underwent MRI-guided needle localization for histopathologic evaluation of the lesions. All interventional procedures were performed in a 3.0 T MRI system with the patient in prone position and by using a dedicated phased array breast coil. MRI-guided needle localizations were performed by using a freehand technique. In our study, the high-resolution scan allowed preprocedural localization of all lesions without use of contrast enhancement. In all cases contrast-enhanced MRI was performed after insertion of the wire to confirm the tip of the wire in direct contact with the enhancing lesion. RESULTS: Needle localizations were performed in five patients. Histopathologic evaluation of tissue after surgery excision biopsy revealed one lymph node, three invasive ductal carcinoma and one ductal carcinoma in situ. Lesion size varied from 6 to 30 mm. Mean duration time was 25 min. No complications occurred during the intervention method. In the patient with the benign lesion control MRI of the breast after 6 months confirmed lesion removal. CONCLUSIONS: MRI-guided needle localization by using a freehand technique in a 3.0 T closed bore magnet is a safe and accurate method for diagnosis of difficult accessible breast lesions only visible on MRI.

Biopsy, Needle↗