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Autologous Fibrin Glue in Pterygium Surgery as an Alternative to Commercial Fibrin Glue.

Márcia Cristina Todo·André Luiz Sita E Souza Bragante·Ananda Lini Vieira da Rocha·Magda Massae Hata Viveiros·Alvio Isao Shiguematsu·Silvana Artioli Schellini
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Abstract

PURPOSE: The aim of this study was to evaluate the efficacy and safety of autologous fibrin glue in pterygium surgery, comparing it with commercial fibrin glue in terms of postoperative complications, graft stability, and recurrence rate. METHODS: A prospective, randomized, double-blind study was conducted, involving 42 patients with primary pterygium who underwent autologous conjunctival-limbal transplantation. The graft was fixed using autologous fibrin glue (Group 1, G1) or commercial fibrin glue (Group 2, G2). All patients underwent surgery performed by the same surgeon and were reevaluated on postoperative days 7, 30, 90, and 180 by an independent observer, assessing clinical parameters in the preoperative, intraoperative, and postoperative periods. RESULTS: No cases of severe adverse events were reported. Complete graft dehiscence occurred in 1 patient from G1. The G2 group had more cases of subconjunctival hemorrhage ( P = 0.0355). Pyogenic granuloma was observed in 1 patient from G2 and 2 patients from G1. There was no significant difference in recurrence rates between the groups (15% in G1 vs. 5% in G2; P = 0.2918). In both groups, graft dimensions tended to decrease slightly in the early postoperative period, followed by stabilization. CONCLUSIONS: Autologous fibrin glue demonstrated efficacy and safety comparable to commercial fibrin glue, making it a viable alternative to conjunctival graft fixation in primary pterygium surgery.

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HumansFibrin Tissue AdhesivePterygiumFemaleDouble-Blind MethodMaleProspective StudiesTissue AdhesivesConjunctivaMiddle AgedAgedTransplantation, AutologousTreatment OutcomeOphthalmologic Surgical ProceduresAdultRecurrencePostoperative ComplicationsGraft Survivalautologouscommercialfibrin gluefibrin tissue adhesivepterygiumrecurrenceJournal ArticleRandomized Controlled Trial

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Márcia Cristina Todo, André Luiz Sita E Souza Bragante, Ananda Lini Vieira da Rocha, Magda Massae Hata Viveiros, Alvio Isao Shiguematsu, Silvana Artioli Schellini. 2025-10-01. Autologous Fibrin Glue in Pterygium Surgery as an Alternative to Commercial Fibrin Glue.. https://doi.org/10.1097/ico.0000000000004012

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