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Crystal properties as indicators of conformational changes during ligand binding or interconversion of Mcg light chain isomers.

K R Ely·J R Firca·K J Williams·E E Abola·J M Fenton·M Schiffer·N C Panagiotopoulos·A B Edmundson
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Bence Jones ProteinHumansImmunoglobulin GImmunoglobulin Light ChainsMacromolecular SubstancesModels, MolecularProtein ConformationX-Ray DiffractionJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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K R Ely, J R Firca, K J Williams, E E Abola, J M Fenton, M Schiffer, N C Panagiotopoulos, A B Edmundson. 1978-01-10. Crystal properties as indicators of conformational changes during ligand binding or interconversion of Mcg light chain isomers.. https://doi.org/10.1021/bi00594a023

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Plasma cell leukemia with pleomorphic plasma cells--a case report.

A case of plasma cell leukemia showing mostly pleomorphic plasma cells in the form of convoluted and multilobated nuclei with some having bilobed nuclei and internuclear bridges is being reported for its rarity of occurrence. Patient presented with congestive cardiac failure and features of nephropathy. There were no lytic lesions in the bone. Serum electrophoresis did not show any M-band while urine electrophoresis demonstrated Bence Jones protein confirming a light chain only type of myeloma. Patient is in remission 5 months after diagnosis. The significance of recognising such pleomorphic plasma cells is discussed.

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