PubMed · 4265236
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W Garn. 1972. [Percutaneous absorption studies using corticoids].. https://pubmed.ncbi.nlm.nih.gov/4265236/
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Steroid hormones are able to influence the metabolism of bone tissue in vivo, but reports regarding their direct action on bone cells fail to agree. In this study, in vitro administration of 17 beta-estradiol, testosterone and corticosterone to normal and otosclerotic osteoblastic cells induced a drop in DNA synthesis in both populations, an increase in the neosynthesis of endocellular proteins in normal cells and a rise, mainly in proteins secreted into the medium, in otosclerotic cells. The fact that 3H-thymidine and 3H-leucine uptake were lower in otosclerotic than in normal cells suggests that the membrane permeability differs in the two populations and that steroids exert an influence on both isotope uptake and directly modulate DNA and protein synthesis.
Serum corticosterone and cortisol concentrations were determined during pregnancy and at delivery in six normal pregnant women. The concentrations of both steroids increased gradually during pregnancy and in late pregnancy they reached values which were 2.5 times those in early pregnancy. The corticosterone concentration increased rapidly immediately after delivery, the values averaging 6.3 times those at the onset of the first labor pain, whereas the cortisol concentration was only about 2.1 times. Although the corticosterone to cortisol concentration ratio was constantly within the normal range throughout pregnancy until delivery, a significant increase in the ratio was observed immediately after delivery (p less than 0.001). It has been known that adrenal secretion of corticosterone in response to exogenous ACTH occurs prior to that of cortisol. Consequently, our results suggest that the dramatic increase in the corticosterone serum concentration after delivery may be due to some physical stress in terms of labor pains, while the steady increase before labor must be due to physiological organic changes characteristic of pregnancy.
A number of glucocorticoids stimulated oestradiol binding to liver cytosol receptor; oestradiol activated glucocorticoid receptor association at a time when it reversed triamcinolone mediated increase in liver glycogen synthesis.