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Tumor evolution shapes metastatic competence in colorectal cancer.

Mathijs P Verhagen·Louis Vermeulen
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Abstract

In this issue of Cancer Cell, Manca et al. investigate the genomic evolution and metastatic tropism of over 7,000 colorectal cancers. Integrating primary tumor location, genomic alterations, and clinical variables, they reveal how distinct patterns of tumor evolution shape metastatic competence and impact organ tropism, offering a framework to refine surveillance.

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HumansColorectal NeoplasmsNeoplasm MetastasisAnimalsJournal ArticleComment

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Mathijs P Verhagen, Louis Vermeulen. 2026-09-01. Tumor evolution shapes metastatic competence in colorectal cancer.. https://doi.org/10.1016/j.ccell.2026.07.013

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