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First draft genome sequence of the emerging sexually transmitted dermatophyte Trichophyton mentagrophytes genotype VII.

Charlotte Reid·Mohamed Adnan Asif Ali·Lara Saivanya·Nicolas Helmstetter·Yaiza Gutierrez Vazquez·Peter Ashton·Rhys A Farrer·Johanna Rhodes·Alireza Abdolrasouli·Andrew M Borman
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Abstract

Trichophyton mentagrophytes ITS-genotype VII (TMVII) is a globally emerging sexually transmitted dermatophyte causing severe skin infections characterised by painful, pustular lesions on the face, public area, genitalia, and trunk. To inform the prevention efforts, we present the first draft genomes of four TMVII isolates obtained from patients in the United Kingdom diagnosed between 2021 and 2025. We performed whole-genome sequencing and phylogenetic analysis based on single-nucleotide polymorphisms. We analysed the genetic relatedness of four TMVII isolates collected from UK patients, two had travel links to Spain and the Middle East. Two further isolates, including T. mentagrophytes ITS-genotype I/II obtained from a canine infection in the United Kingdom in 2025 and Trichophyton indotineae were sequenced for contextual analysis. We confirm that the TMVII strains studied here represent a highly clonal population, distinct from both zoophilic T. mentagrophytes genotype I/II and anthropophilic T. indotineae.

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HumansGenotypeAnimalsPhylogenyPolymorphism, Single NucleotideGenome, FungalWhole Genome SequencingUnited KingdomArthrodermataceaeTineaDogsTrichophyton mentagrophytes genotype VIIdermatophytosisemerging fungifungal genomicsgenome assemblypathogen genomicssequencingJournal Article

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Charlotte Reid, Mohamed Adnan Asif Ali, Lara Saivanya, Nicolas Helmstetter, Yaiza Gutierrez Vazquez, Peter Ashton, Rhys A Farrer, Johanna Rhodes, Alireza Abdolrasouli, Andrew M Borman. 2026-08-29. First draft genome sequence of the emerging sexually transmitted dermatophyte Trichophyton mentagrophytes genotype VII.. https://doi.org/10.1093/mmy%2Fmyag065

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