PubMed · 4270418
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B Petchclai, R Chutanondh, S Prasongsom, S Hiranras, T Ramasoota. 1973. Complement profile in leprosy.. https://doi.org/10.4269/ajtmh.1973.22.761
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Phagocytosis by adherent human monocytes of human erythrocytes (RBC), sulfatide-enriched by incubation with 10(-12) to 10(-9) M cerebroside sulfate, was enhanced approx. 6-fold. Increased phagocytosis was observed only in RBC opsonized with fresh plasma, and not in non-opsonized or serum-opsonized RBC. Increased phagocytosis was immunoglobulin- and complement independent. Thrombospondin and von Willebrand factor, present in plasma but not in serum, and binding selectively to sulfatides, are likely mediators of the enhanced phagocytosis.
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