PubMed · 4368153
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J C Fruchart, G Sezille, J Jaillard, E Decoopman, C Desreumeaux. 1974. [Hyperlipemia and lipoproteinogram].. https://pubmed.ncbi.nlm.nih.gov/4368153/
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A facile, two-step synthesis of the bis(hydroxamamide)-based tetradentate ligands for 99mTc-radiopharmaceuticals is described. Firstly, the hydroxamamide was converted to hydroximic acid chloride by reaction with sodium nitrite in hydrochloric acid at 0 degrees C. Secondly, treating the halide with the ethylenediamine or 1,3-propylenediamine in absolute ethanol formed the desired products, N,N'-ethylene bis(1-(4-nitroimidazole-1-yl)-propan-hydroxyiminoamide) (I) and N,N'-propylene bis(1-(4-nitroimidazole-1-yl)-propanhydroxyiminoamide) (II). The corresponding 99mTc complexes showed high yields and were found by paper electrophoresis to be electrically neutral under physiological conditions. The partition coefficients indicated a distinct difference between the two complexes.
Iontophoresis is the process of increasing the penetration of drugs for therapeutic purposes using DC electricity. The most important factor for iontophoresis is the formation of drug ions in solution. On this basis, the penetration of any drug applied by iontophoresis might be maximized at an optimal pH. Seven medications were investigated: acyclovir, methylprednisolone sodium succinate, metronidazole, dexamethasone sodium phosphate, minoxidil, lidocaine hydrochloride, and adenine arabinoside monophosphate. Using techniques of paper electrophoresis, we evaluated the influence of pH on the mobility (mu) of the drugs in phosphate buffers at pH 5, 7, and 9. The mu-values were calculated after detecting the drugs on paper with ultraviolet light. The results indicate that the seven drugs had higher mu-values usually at one, but sometimes at two, of the pH values studied. This study suggests that a variation in pH might alter the maximum ionization, and therefore, the optimal mobility for these seven drugs, as well as other drugs, suited to iontophoresis.
Haptoglobin concentration was determined from the change caused in the absorption spectrum of hemoglobin due to binding with haptoglobin. Absorbance changed markedly near the Soret band, and a linear correlation could be observed between the extent of the absorbance change and the amount of free haptoglobin. The levels of serum haptoglobin measured by the present method correlated well with those determined by an electrophoretic or a peroxidase method. High concentrations (more than 10 mg/100 ml) of hematin gave positive interference in the measured haptoglobin level, whereas bilirubin and chylomicron showed low levels of interference. The proposed method could be used as a simple and reliable method for the determination of haptoglobin level in various types of sample.