PubMed · 4429362
The source did not provide an abstract. Follow the original record for more information.
Explore connections, maps & timelines
B M Frier, V J Marrian. 1974. Uncomplicated hyperparathyroidism.. https://doi.org/10.1136/adc.49.10.808
Cite the original work for its findings. Save a collection to share your selection of sources.
KEEP EXPLORING
The cuticle of the adult abdomen of Drosophila is produced by nests of imaginal histoblasts, which proliferate and migrate during metamorphosis to replace the polyploid larval epidermal cells. In this report, we present a detailed description of the expression of four key patterning genes, engrailed (en), hedgehog (hh), patched (ptc), and optomotor-blind (omb), in abdominal histoblasts during the first 42 h after pupariation, a period in which the adult pattern is established. In addition, we describe the expression of the homeotic genes Ultrabithorax, abdominal-A, and Abdominal-B, which specify the fates of adult abdominal segments. Our results indicate that abdominal segments develop in isolation from one another during early pupal stages, and that some patterning events are independent of hh, wingless, and decapentaplegic signaling. We show that pattern and polarity in a large anterior portion of the segment are specified without input from Hh, and present evidence that abdominal tergites possess an underlying symmetric pattern upon which patterning by Hh is superimposed. The signals responsible for this underlying symmetry remain to be identified.
The authors previously reported an interaction of waist/hip ratio and family history on the risk of breast cancer in the Iowa Women's Health Study. Here they reexamine this association based on 9 additional years of follow-up, stratifying on tumor receptors for estrogen and progesterone. Data on risk factors and family history of breast cancer were ascertained in 1986. The occurrences of breast cancer and estrogen receptor/progesterone receptor were determined through the Iowa Surveillance, Epidemiology, and End Results' registry. Rate ratios were elevated with increasing weight and body mass index and decreasing body mass index at age 18 years, but they did not vary by family history. There was no association with height, waist circumference, or waist/hip ratio. A linear trend of increasing risk with increasing waist/hip ratio was observed among family history-positive women (p = 0.06) but not among family history-negative women (p = 0.87). This apparent interaction (p = 0.09) was examined by estrogen receptor or progesterone receptor status. When stratified on family history and estrogen receptor, no clear patterns were evident. In contrast, family history-positive women in the upper quintile of the waist/hip ratio were at 2.2-fold greater risk of progesterone receptor-negative tumors compared with those in the lowest quintile (95% confidence interval: 0.9, 5.8). Thus, the previously reported interaction between family history and waist/hip ratio is still (weakly) evident and appears to reflect risk for progesterone receptor-negative tumors.
STUDY DESIGN: This study examined the effect of a belt on ventilation and trunk muscle activities during repetitive lifting tasks with a control of breathing type and belt pressure. OBJECTIVES: To evaluate the effect of the lifting belt on the trunk muscle electromyography (EMG) and to parse out potential interaction between ventilatory changes and lifting belts. SUMMARY OF BACKGROUND DATA: Although both tensed thorax and compressed abdomen are considered to assist transferring the force from torso to pelvis in lifting, there has not been any consideration of the interaction between the two chambers in most published analyses. METHODS: Eleven male study participants participated in the study. They performed five minutes of paced repetitive squat lifts at frequencies of one or three lifts per minute, with loads of 10 or 25 kg. Belt pressure was set at 0 (no belt), 10, and 20 mm Hg. Study participants lifted with inspire-hold and expire-hold for a period of 5 minutes. Lift ventilation data and trunk muscle normalized electromyography (NEMG) (including rectus abdominis, external oblique, latissimus dorsi, and erector spinae) for the final lift were collected for analysis. RESULTS: The results indicate that the ventilation demand for lifting was not different with or without use of a belt. The prelifting erector spinae NEMG was 8-11% maximum voluntary contraction (MVC) lower and the latissimus dorsi NEMG was 15-21% MVC lower than that without belt. This is also the case in the lifting phase. The rectus abdominis NEMG was increased by 4% MVC and the external oblique NEMG was increased by 3-5% MVC while lifting with a belt. CONCLUSIONS: These data do not lead to a statistical effect of lifting belt pressure on ventilatory behavior. It appears that the use of a belt in lifting significantly decreased the back muscular activation yet increased the abdominal muscular activation. Thus, claims of benefits derived from the use of a belt in lifting remain controversial. The simultaneous controls of the air volume held and pressure of the belt during the moment-controlled lifting tasks allowed this presentation of belt effects on trunk muscle NEMG unique from that in most of the literature.