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PubMed · 4501587

Electromechanochemical model of mitochondrial structure and function.

D E Green·S Ji
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Abstract

A NEW MODEL OF MITOCHONDRIAL STRUCTURE AND FUNCTION IS PROPOSED ON THE BASIS OF FOUR FUNDAMENTAL ASSUMPTIONS: (a) electrons and protons are separated in the electron transfer complexes; (b) the ATPase undergoes conformational state-transitions induced by an electric field; (c) energy is transferred by an electric field effect; and (d) a conformationally strained protein system can be relaxed via a bond-forming chemical reaction. The model can explain all of the mitochondrial coupled processes and, in addition, it provides a reasonable rationalization of the correlation between mitochondrial structure and function.

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Biological Transport, ActiveElectron TransportEnergy TransferMitochondriaModels, BiologicalModels, ChemicalOxidative PhosphorylationPotassiumJournal Article

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D E Green, S Ji. 1972. Electromechanochemical model of mitochondrial structure and function.. https://doi.org/10.1073/pnas.69.3.726

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