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PubMed · 45436

[Pulmonary resistance in shock: changes in beta-mimetics].

M Cagossi·G Nanni·A Borzone·M Turno·A Butti
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Adrenergic beta-AgonistsAnimalsDogsIsoproterenolLungLung CompliancePulmonary CirculationShock, HemorrhagicVascular ResistanceEnglish AbstractJournal Article

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M Cagossi, G Nanni, A Borzone, M Turno, A Butti. 1979. [Pulmonary resistance in shock: changes in beta-mimetics].. https://pubmed.ncbi.nlm.nih.gov/45436/

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In vitro modulation of CNS beta-receptor number by antidepressants and beta-agonists.

In vitro incubation of rat cerebral cortex slices with antidepressant drugs reduced beta-adrenergic receptor binding of 3H-dihydroalprenolol by 30%. The decrease was maximum after 60 min, and was reversible after 120 min. (-)-Isoproterenol incubation caused a rapid and reversible loss (60%) of beta-receptor binding. Both effects were due to a decrease in beta-receptor sites. In vitro beta-receptor subsensitivity due to desipramine and isoproterenol was non-additive. The observed reversible loss of beta-receptor sites may be an initial phase of the beta-receptor down-regulation by antidepressants seen in vivo.

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