PubMed · 4559984
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H L Bleich. 1972. Computer-based consultation. Electrolyte and acid-base disorders.. https://doi.org/10.1016/0002-9343(72)90170-2
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Abstract Saccharomyces cerevisiae has only one putative gene (designated CPL1) for a cysteine protease with a protease domain similar to that of calpain. This gene product shows significant sequence similarity to PalBp, a fungal (Emericella nidulans) calpain-like protease that is responsible for adaptation under alkaline conditions, both in the protease domain and the domain following the protease domain. CPL1 disruptant strains show impaired growth at alkaline pH, but no obvious growth defects under acidic pH conditions. This phenotype is complemented by the wild-type CPL1 gene, and its protease activity is essential for complementation. Disruption of CPL1 also causes reduced sporulation efficiency and promotes the degradation of the transcription factor Rim101p, which is involved in the sporulation pathway and has been shown to accumulate in a C-terminally truncated, active form under alkaline conditions. Furthermore, expression of the C-terminally truncated Rim101p suppressed the alkaline sensitivity associated with CPL1 disruption. These results indicate that a calpain-like cysteine protease, Cpl1p, plays an important role in alkaline adaptation and sporulation processes, via regulation of the turnover and processing of the transcription factor Rim101p.
Sinusoidal fetal heart rate may have a spectrum of occurrence that indicates degree of fetal morbidity. Twelve cases of intermittent sinusoidal fetal heart rate were reviewed for fetal outcome. Findings of anemia, low umbilical cord pH, and large base excess support that intermittent sinusoidal fetal heart rate may be an early indicator of impending fetal compromise.
PURPOSE: We assess the functional importance of a colorectal valve in patients with rectal urinary diversion. MATERIALS AND METHODS: A retrospective evaluation of 87 patients with an anal sphincter controlled bladder substitute was performed. Of these patients 42 had colorectal valves and 45 did not. Evaluation included serum chemistry studies and arterial blood samples to study the impact of the colorectal valve on homeostasis. RESULTS: There was a statistically significant difference between the 2 groups in pH, carbon dioxide partial pressure, bicarbonate, base excess and chloride in favor of patients with a colorectal valve. CONCLUSIONS: The difference between the groups was reduction of the surface area available for reabsorption when a valve is constructed. This finding is of particular importance among patients with a long life expectancy. Prophylactic alkalization is necessary in cases without valve reconstruction.