PubMed · 4576263
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R I Kohut, W Adkins. Control for vacuum embedding methods in temporal bone histopathology.. https://doi.org/10.1177/000348947308200323
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The formation of plaques by lambda phage in Escherichia coli was prevented by elevated hydrostatic pressure; phage plaques were not detected at 30 MPa. Furthermore, using promoter fragments derived from the malB operon, we showed that gene expression initiated from both promoters (malK-lamB and malEFG) was repressed by elevated hydrostatic pressure. Our findings suggest that high pressure affects gene expression directed by the malB regulatory interval, and this may cause a decrease in the quantities of lambda receptor protein, LamB.
OBJECTIVE: Our purpose was to determine whether there is a relationship between changes in atmospheric pressure and spontaneous onset of labor in term pregnancy. STUDY DESIGN: All women admitted to Medical Center of Central Massachusetts-Memorial Hospital with spontaneous onset of labor at term and who were delivered on the service during a 12-month period represent the cohort for this study. Each maternal chart was abstracted to ensure that each member of the cohort met the inclusion criteria. Hourly recordings of atmospheric pressure made at the Worcester Station of the National Weather Service, Department of Commerce, were used as the meteorologic data points of interest. Least-squares regression was used to determine an equation that expresses the probability of the onset of labor in this cohort as a function of gestational age, which was used to calculate expected numbers for the statistical analyses. Two relationships were studied: (1) the ratio of the observed to the expected number of onsets of labor and (2) the initiation of labor and atmospheric pressure changes in the preceding 3 hours. RESULTS: Three-hour periods of falling atmospheric pressure were less often followed by initiation of labor than were the periods with other types of pressure sequences. No association was observed between the onset of labor and days of low mean pressure. CONCLUSION: Although there was an observed statistically significant association between falling barometric pressure and onset of labor, the magnitude of the difference is not of clinical significance.
Psychotic-like episodes in divers exposed to high pressure have been attributed to either the high-pressure neurological syndrome, confinement in pressure chamber, the subject's personality, or the addition of nitrogen or hydrogen to the basic helium-oxygen breathing mixture used for deep diving. Alternatively, it is suggested that these disorders are in fact paroxysmal narcotic symptoms that result from the sum of the individual narcotic potencies of each inert gas in the breathing mixture. This hypothesis is tested against a variety of lipid solubility theories of narcosis. The results clearly support the hypothesis and provide new information about the cellular interactions between inert gases at raised pressure and pressure itself.