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PubMed · 4795926

Hyperactivity and brain catecholamines in lead-exposed developing rats.

M W Sauerhoff·I A Michaelson
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Abstract

Newborn rats that suckled mothers eating a diet containing 4 percent lead carbonate display hyperactivity, aggressiveness, and excessive stereotyped behavior starting at 4 weeks of age. There is an eightfold increase in the concentration of lead in brain, no change in norepinephrine, but a 20 percent decrease in dopamine relative to coetaneous controls. This suggests a relationship between central nervous system dysfunction due to lead and dopamine metabolism in brain.

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AggressionAnimalsAnimals, NewbornBehavior, AnimalBrainBreast FeedingCatecholaminesDopamineFemaleGroomingHumansHyperkinesisLeadLead PoisoningNorepinephrineRatsStereotyped BehaviorJournal Article

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M W Sauerhoff, I A Michaelson. 1973-12-07. Hyperactivity and brain catecholamines in lead-exposed developing rats.. https://doi.org/10.1126/science.182.4116.1022

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