Hyperammonemia associated with perinatal asphyxia.

R N Goldberg; L A Cabal; F R Sinatra; C E Plajstek; J E Hodgman

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PubMed · 481980

Hyperammonemia associated with perinatal asphyxia.

R N Goldberg·L A Cabal·F R Sinatra·C E Plajstek·J E Hodgman

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Abstract

Twelve infants with severe perinatal asphyxia were found to have elevated blood ammonia levels (302 to 960 microgram/100 ml). In the seven survivors, hyperammonemia was associated with CNS irritability, hyperthermia, hypertension, and wide neonatal heart rate oscillations. Follow-up examinations revealed severe neurologic dysfunction in five of seven infants. CNS depression, hyperthermia, hypertension, and a nonreactive, fixed heart rate characterized the infants that died. These findings suggest a clinical entity secondary to perinatal asphyxia whose signs and symptoms may be related to hyperammonemia.

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Ammonia Asphyxia Neonatorum Female Fever Follow-Up Studies Heart Rate Hepatic Encephalopathy Humans Hypertension Infant, Newborn Infant, Newborn, Diseases Male Journal Article

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R N Goldberg, L A Cabal, F R Sinatra, C E Plajstek, J E Hodgman. 1979. Hyperammonemia associated with perinatal asphyxia.. https://pubmed.ncbi.nlm.nih.gov/481980/

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