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PubMed · 4970764

Human prothrombin activation.

S S Shapiro
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Abstract

Antiserums to human prothrontbin contain antibodies directed against at least two different antigenic sites. During blood coagulation, prothrombin is cleaved into two major antigenically distinct fragments-thrombin and a "pro" fragment. The latter is present in normal seruim, whereas thrombin loses its immunologic reactivity, presumably because of its combination with the natural thrombin inhibitors in blood.

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Antigen-Antibody ReactionsBlood CoagulationHumansImmune SeraImmunochemistryImmunodiffusionImmunoelectrophoresisProthrombinJournal Article

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S S Shapiro. 1968-10-04. Human prothrombin activation.. https://doi.org/10.1126/science.162.3849.127

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