PubMed · 4999568
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J R May, A Ingold. 1971-10-02. Epiglottitis in adults.. https://doi.org/10.1136/bmj.4.5778.46
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Penicillin sulfones, which structurally incorporate both a 6-position alkylidene substituent and a 2'beta substituent, have been synthesized and evaluated as inhibitors of class C and class A serine beta-lactamases. Incorporation of the 2'beta-substituent generally improves inhibitory activity. Substituents that improve transport across the bacterial cell membrane have also been incorporated.