Perinatal naloxone: when does naloxone affect hyperalgesia?

H Monder; N Yasukawa; J J Christian

doi:10.1016/0091-3057(79)90020-0

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Perinatal naloxone: when does naloxone affect hyperalgesia?

H Monder·N Yasukawa·J J Christian

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Abstract

Pregnant mice were treated with naloxone via subcutaneous implants, from about 5 days prior to parturition. At birth entire litters were cross-fostered so that groups of offspring were exposed to naloxone treated mothers; before birth, after birth to weaning, from about 5 days prior to birth to weaning, or not exposed to naloxone. When tested on a hot-plate at 50 days of age, females either prenatally treated or treated pre- and postnatally showed hyperalgesia to heat. For males, this effect was not evident. This sex difference may have been induced by the cross-fostering procedure.

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Aging Animals Body Weight Female Hyperalgesia Hyperesthesia Male Mice Naloxone Reaction Time Sex Factors Time Factors Journal Article Research Support, U.S. Gov't, P.H.S.

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H Monder, N Yasukawa, J J Christian. 1979. Perinatal naloxone: when does naloxone affect hyperalgesia?. https://doi.org/10.1016/0091-3057(79)90020-0

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