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PubMed · 504791

Single point clearance estimation.

J R Koup·J T Slattery·M Gibaldi
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Abstract

Linear relationships were observed between the log of total body clearance (C1B) and simulated serum concentrations (Cmin) six hours after a test dose of chloramphenicol, as well as between C1B and the reciprocal of Cmin. Correlation coefficients for these relationships were 0.988 and 0.977, respectively. Clearance estimates obtained from a single serum sample following a test dose of a drug may prove to be a useful method of predicting dosage requirements for individual patients.

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ChloramphenicolHumansKineticsModels, BiologicalJournal Article

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J R Koup, J T Slattery, M Gibaldi. 1979. Single point clearance estimation.. https://pubmed.ncbi.nlm.nih.gov/504791/

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