PubMed · 5073535
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C Y Chow, Y C Lai. 1972. Alternating flow in trachea.. https://doi.org/10.1016/0034-5687(72)90085-0
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Recently, we reported that freely moving Flinders sensitive line rats (FSL, selectively bred for their cholinergic hyperresponsiveness) are more susceptible to allergen-induced airway hyperresponsiveness than their control counterparts-Flinders resistant line (FRL) rats. In this study the two Flinders lines were compared for responsiveness of excised tracheal and primary bronchial smooth muscle in vitro. FSL tissues were slightly but significantly more sensitive to cholinergic stimulation than FRL tissues (slightly lower EC(50) value for carbachol) but the FRL tissues were more responsive, exhibiting larger amplitude of response. Surprisingly, previous exposure to allergen challenge was accompanied by reduced in vitro responses to spasmogens in both rat lines. We conclude that FSL and FRL airways do not differ greatly with respect to sensitivity to cholinergic stimulation in vitro and that inflamed airways show reduced in vitro responses to spasmogens. The discrepancy between the in vivo and in vitro findings suggests that responsiveness of airway smooth muscle involves regulation from both proximal and distal sites.
Respiratory muscle strength can be assessed by measurement of maximal inspiratory (PIMAX) and maximal expiratory pressure (P(EMAX)) during crying. There are, however, relatively few data on P(IMAX) and P(EMAX) in infancy, particularly from those born preterm. Our aim was to investigate which factors influenced P(IMAX) and P(EMAX) in preterm and term infants. Forty infants, median gestational age 37 weeks (range 26-43) and birthweight 2.579 kg (range 0.956-5.180) were studied at a postconceptional age (PCA) of 38 weeks (range 32-44). None had respiratory problems. A facemask was placed firmly over the infant's mouth and nose and the infant studied during spontaneous crying. A pneumotachograph fitted snugly into the facemask and from a sideport airway pressure changes were measured. During crying, the distal end of the pneumotachograph was occluded for five breaths and at least three separate occlusions were made. The highest P(EMAX) value sustained for at least 1 s and the highest peak inspiratory pressure P(IMAX) were recorded. The mean P(IMAX) and P(EMAX) were higher in the term compared to the preterm infants (70 cmH2O +/-S.D. 19 versus 58 cmH2O +/-S.D. 17 P(IMAX) and 53 cmH2O +/-S.D. 13 versus 44 cmH2O +/-S.D. 19 P(EMAX), P< 0.05). Both P(IMAX) and P(EMAX) related significantly with postconceptional age, gestational age and weight, but not postnatal age. Stepwise regression analysis demonstrated P(IMAX) related independently with PCA and P(EMAX) with weight. These results suggest respiratory muscle strength is influenced by maturation at birth.
OBJECTIVE: To assess the pneumatic performances of six new anaesthesia ventilators. STUDY DESIGN: Bench test study. MATERIAL: The study included one ventilator operated by an electric motor: ABT 5300 (Kontron); four ventilators of "bellows-in-bottle" category: ADU version 97 (Datex-Ohmeda); Aestiva 3000 (Datex-Ohmeda), Kion (Siemens), the two versions of Julian (Dräger); and an original ventilator devised for quantitative, or self-regulating target controlled inhalation anaesthesia, with a totally closed circuit, made of four ventilating chambers: PhysioFlex (Dräger). METHODS: The bench test included a passive lung model with adjustable compliance and resistances, and flow and pressure gauges. The accuracy of volume and pressure measurements was tested in various conditions of resistance and compliance. RESULTS: Pneumatic performance and accuracy were satisfactory, even in severe ventilatory conditions. All the ventilators, except ABT 5300 and Julian 1, have a compliance compensation system permitting to deliver and to maintain a constant tidal volume under various conditions of downstream load, particularly under maximal load condition. Variations of tidal volume with the increase of the fresh gas flow are negligible. CONCLUSION: Recent technological progress has improved pneumatic performance of anaesthesia ventilators and the marketed models are more homogeneous at present. Ergonomics and training for the use of the machine are becoming major criteria for the global assessment and the choice of a ventilator.