Reverse transcriptase associated with A-type particles from murine myeloma cells.

R E Thach; D L Robertson; N L Baenziger; D C Dobbertin

doi:10.1101/sqb.1974.039.01.110

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Reverse transcriptase associated with A-type particles from murine myeloma cells.

R E Thach·D L Robertson·N L Baenziger·D C Dobbertin

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Abstract

Our findings may be summarized as follows: (a) a DNA polymerase is associated with murine type A particles, which is very similar to the reverse transcriptases found in true RNA tumor viruses; (b) the majority of the RNA isolated from A particles is of low molecular weight (probably due to degradation), byt appears to contain an amount of unique sequence information comparable to that found in other oncornavirus particles. These results suggest that A-type particles may be very similar, and perhaps related, to the two other classes (B and C) of oncornaviruses.

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Base Sequence Cells, Cultured DNA Kinetics Molecular Weight Multiple Myeloma Oncogenic Viruses RNA RNA Viruses RNA, Viral RNA-Directed DNA Polymerase Journal Article Research Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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R E Thach, D L Robertson, N L Baenziger, D C Dobbertin. 1975. Reverse transcriptase associated with A-type particles from murine myeloma cells.. https://doi.org/10.1101/sqb.1974.039.01.110

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