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PubMed · 5096365

Ultrastructure of the normal lymph node.

C Nopajaroonsri·S C Luk·G T Simon
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Abstract

The "normal" lymph node has been studied by electron microscopy. The lymphoid tissue can be divided into three distinct zones. Zone 1 consists of loosely arranged cells surrounding the lymphatic sinuses and blood vessels. This is the only zone in which plasma cells are present. Zone 2 is surrounded by zone 1 and consists of compactly arranged cells in which lymphocytes predominate. Zone 3 (germinal center) appears only after antigenic stimulation. It is characterized by large, ribosome-rich cells and macrophages containing phagocytosed lymphocytes. These zones are arranged with their longest diameters pointing towards the hilus. Zone 1 is the longest and extends across the cortex, paracortex and medulla. Zone 2 spans across cortex and paracortex. Zone 3 usually is confined to the cortex. Our preliminary studies indicate that zone 1 is mainly bursal dependent, zone 2 is mainly thymic dependent and zone 3 is bursal dependent.

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AnimalsCapillariesCollagenFemaleFibroblastsLymph NodesLymphocytesMacrophagesMicroscopy, ElectronPlasma CellsRatsRats, Inbred StrainsReticulocytesJournal Article

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C Nopajaroonsri, S C Luk, G T Simon. 1971. Ultrastructure of the normal lymph node.. https://pubmed.ncbi.nlm.nih.gov/5096365/

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