Permeability factor contaminating hyaluronidase preparations.

J C Houck; C M Chang

doi:10.1007/bf00913502

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Permeability factor contaminating hyaluronidase preparations.

J C Houck·C M Chang

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Abstract

Both crude and highly purified testicular hyaluronidase preparations have been shown to contain a component which increases the permeability of the microcirculation in rat skin. This permeability activity had an isoelectric point of 7.4 while hyaluronidase was 9.4. It also could be separated from hyaluronidase by acrylamide gel electrophoresis. The permeability factor was not inhibited by serum and may explain previous observations that hyaluronidase preparations decrease the ischemia and necrosis appropriate to experimental myocardial infarction in vivo.

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Animals Capillaries Capillary Permeability Drug Contamination Electrophoresis, Polyacrylamide Gel Hyaluronoglucosaminidase Isoelectric Focusing Male Rats Skin Testis Journal Article Research Support, U.S. Gov't, Non-P.H.S.

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J C Houck, C M Chang. 1979. Permeability factor contaminating hyaluronidase preparations.. https://doi.org/10.1007/bf00913502

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