PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 512861

ADS-12: an automated programmable 12-tablet dissolution testing system.

F J Cioffi·S Martynovych·H Bendrot
View original source ↗Export metadata ↓

Abstract

A novel computerized automated system is described which conforms to the basic requirements set forth in the compendia for testing the dissolution characteristics of solid dosage forms. This modular system can test 12 tablets simultaneously. It can maintain sink conditions at all times and can handle any chemistry amenable to an automatic analyzer. Dissolution, sampling, chemistry, and readout are all accomplished simultaneously, reducing the complete test time for 12 tablets to the dissolution time itself.

Explore related subjects

Chemistry, PharmaceuticalComputersErythromycinPenicillin GPrednisoneSalicylatesSolubilitySpectrophotometry, UltravioletTabletsJournal Article

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

F J Cioffi, S Martynovych, H Bendrot. 1979. ADS-12: an automated programmable 12-tablet dissolution testing system.. https://doi.org/10.1002/jps.2600681022

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed1992

Mirror images: the analysis of pharmaceutical enantiomers.

Pharmaceutical enantiomers often exhibit different pharmacodynamic and pharmacokinetic properties. Stereospecific chromatographic assays are available to separate these stereoisomers. Therapeutic agents often contain chemical functional groups (e.g. amino, hydroxyl, carbonyl, and carboxylic acid). These can be reacted with enantiomerically pure reagents to give diastereoisomers suitable for analysis on achiral gas chromatographic (GC) and high performance liquid chromatographic (HPLC) columns. Alternatively, derivatized or underivatized drugs may be resolved on chiral chromatographic phases. A wide variety of GC (e.g. amino acid, cyclodextrin, and metal-complex) and HPLC (mobile phase additive, crown ether, pi-pi interaction and related phases, protein, cyclodextrin, polysaccharide, methacrylate and amide polymer, and ligand exchange) columns are commercially available. This article reviews the chromatographic separation of enantiomers.

Chemistry, Pharmaceutical↗
PubMed1992

Modeling of the kinetics of drug release from a binary system.

A model of a controlled-release drug delivery system was proposed and tested by mathematical simulation. The model consisted of a cylindrical drug reservoir coated with a permeable and erodible material. The release rate is relatively constant because, while the drug concentration is diminishing, the barrier is eroding. These factors may be balanced initially, but ultimately the release rate increases or decreases markedly depending on the permeability. Two kinds of permeability-dependent behaviors were observed: (1) for high-permeability coatings, the release rate is high and constant and then decreases as the drug is exhausted; and (2) for low-permeability coatings, the release rate is low and constant and then increases as the barrier becomes thin. The proposed design combines two cylinders whose coatings have different permeabilities and exhibit complementary release behavior. Complete release occurs before total erosion of either coating. Optimization of the design and the design parameters leads to a constant release rate (within 6%) until all of the drug is released from the device.

Chemistry, Pharmaceutical↗